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Universiteit Utrecht
3Rs-Centre Utrecht Life Sciences
Newsletter, December 2018
The mission statement of the 3Rs-Centre Utrecht Life Sciences (ULS) is to stimulate the development, acceptance and implementation of methods which can Replace, Reduce and Refine (the 3Rs) animal experiments. The Centre facilitates the 3Rs in education and animal research in many ways, by providing information and advice about 3Rs models.

Realistic toxicity testing by combining lungs and nervous system in vitro
Combine lungs and the nervous system in vitro, to measure the toxicity of substances. That is what dr. Remco Westerink and his colleagues want to achieve with their research. At the Institute for Risk Assessment Sciences (IRAS), part of the Faculty of Veterinary Medicine at Utrecht University, they have developed a model that has the potential to replace inhalation studies with living animals.
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Animal Free Research UK and 3Rs-Centre Utrecht Life Sciences continue their partnership towards the replacement of animals in research
The 3Rs-Centre Utrecht Life Sciences (ULS) and Animal Free Research UK share the ambition to end the use of foetal calf serum (FCS, or FBS) in cell and tissue culture research. With this vision in mind, they developed the FCS-free Database ( together in 2017. Now, Animal Free Research UK has underlined its partnership with the 3Rs-Centre ULS by providing generous financial support for the database in the upcoming three years. The partnership with Animal Free Research UK will increase the impact the website has on both the replacement of animals used in research and the reproducibility of in vitro studies.
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Publication: One science-driven approach for the regulatory implementation of alternative methods: A multi-sector perspective
EU regulations call for the use of alternative methods to animal testing. During the last decade, an increasing number of alternative approaches have been formally adopted. In parallel, new 3Rs-relevant technologies and mechanistic approaches have increasingly contributed to hazard identification and risk assessment evolution. In this changing landscape, an EPAA meeting reviewed the challenges that different industry sectors face in the implementation of alternative methods following a science-driven approach.
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The Chemical Compliance Coach for foetal calf serum-free chemicals testing
The Chemical Compliance Coach is a consultancy with expertise in the fields of chemistry, (eco-)toxicology and chemicals legislation. The company stands for scientific integrity, regulatory compliance and social responsibility. As animal welfare is of great importance to them, they seek to actively support (scientific) developments leading to a future of animal free chemicals testing. As of 2018, they support the 3Rs Database Programme of the 3Rs-Centre ULS, specifically the Foetal Calf Serum (FCS)-free Database
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Register for the Applied In Vitro Toxicology Course in Romania
The European Society of Toxicology In Vitro (ESTIV) and the American Society for Cellular and Computational Toxicology (ASCCT) are pleased to announce that the next ESTIV Applied In Vitro Toxicology Course will take place in Bucharest, Romania, on April 14-19, 2019. Early-bird registration deadline is 27 December 2018.
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Video on Type 2 Diabetes research without the use of animals
Non-animal research often means better research. This is beautifully illustrated by a study on type 2 diabetes, funded by Animal Free Research UK. They provide an illustrative video on this diabetes project, also called 'the sugar mouse appeal'.
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Publication: 3S – Systematic, Systemic, and Systems Biology and Toxicology
Toxicology contains the somewhat arbitrary subclass “systemic toxicities”; however, there is no relevant toxic insult or general disease that is not systemic. At least inflammation and repair are involved that require coordinated signaling mechanisms across the organism. However, the more body components involved, the greater the challenge to recapitulate such toxicities using non-animal models. Here, the shortcomings of current systemic testing and the development of alternative approaches are summarized.
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Organ-on-Chip showcases call open for application
The Top Sector Life Sciences & Health stimulates the research and development of Organ-on-Chip technology. This field of technology offers our society and healthcare system great opportunities to treat diseases in a personalized way. In addition, the technology can lead to the reduction of animal experiments by development of alternative preclinical test models. To enhance the R&D and develop Organ-on-Chip showcases the Top Sector established the Health~Holland Organ-on-Chip Showcases (HHOOCS) programme.
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Support our activities!
The 3Rs-Centre ULS maintains the 3Rs databases: The Humane Endpoints Websitethe Interspecies Database and the FCS-free Database. These websites contribute to the refinement, reduction and replacement of animals used for research and are free of charge for their users. The website does not receive any financial support and their future relies on donations and gifts. You can help us with keeping these websites available for free by donating a small amount of money for the maintenance and updating of these databases. We are happy with all donations! The 3Rs Programme is part of the charitable fund Friends of VetMed, and as such is exempt from any gift or inheritance taxes. This means that 100% of your donation will contribute towards the purpose specified by you.
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Take a look at international workshops, conferences, meetings and online webinars in the online events calendar of the 3Rs-Centre ULS.
Events       »

Happy Holidays!
We will bring more news on the 3Rs in 2019! The 3Rs-Centre ULS wishes all of our readers a Merry Christmas and a Happy New Year!
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(+31) 30-2538009

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