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Universiteit Utrecht
3Rs-Centre Utrecht Life Sciences
Newsletter, August 2018
The mission statement of the 3Rs-Centre Utrecht Life Sciences (ULS) is to stimulate the development, acceptance and implementation of methods which can Replace, Reduce and Refine (the 3Rs) animal experiments. The Centre facilitates the 3Rs in education and animal research in many ways, by providing information and advice about 3Rs models.

3Rs implementation in Developmental and Reproductive Toxicity (DART) Testing
“Involve the contract laboratories at an early stage in the process of developing and validating new replacement methods”. This is one of the most important recommendations from the thesis of dr. Manon Beekhuijzen. She works at Charles River Laboratories as head of the Developmental and Reproductive Toxicity (DART) department, where safety tests are carried out on new substances before they are brought to the market. She recently obtained her PhD at Utrecht University on the subject of implementation of the 3Rs in DART testing.
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FCS-free Database nominated for Lush Prize
The FCS-free Database ( has been nominated for the Lush Prize 2018. The Lush Prize rewards initiatives across science and campaigning that work to end or replace animal testing, particularly in the area of toxicology research. The 2018 Lush Prize offers a global prize fund of £350,000 across five award categories: Lobbying, Training, Public Awareness, Science, and Young Researchers. was initiated by the 3Rs-Centre ULS, in collaboration with Animal Free Research UK. The Lush Prize winners will be announced in November.
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Long awaited collection of CoP’s published on 3Rs-Centre ULS website
In cooperation with the National Committee for the protection of animals used for scientific purposes (NCad), and the Dutch Animal Welfare Body Platform, the 3Rs-Centre ULS has published a collection of Codes of Practice (CoP’s) in the field of laboratory animal science, both from the Netherlands and other countries worldwide. This is the start of an update of Dutch CoP’s, with the ultimate goal of pursuing good quality animal research and adherence to the 3R principles. The 3Rs-Centre ULS welcomes other CoP’s to add to this inventory.
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OECD adopts Guidance Document on Good In Vitro Method Practices
The Organisation for Economic Co-operation and Development (OECD) adopted the “Guidance Document on Good In Vitro Method Practices" (GIVIMP), the most extensive guidance document for developing and using in vitro methods currently available. This document also discusses alternatives to FCS, and refers to the FCS-free Database as a useful tool to find FCS-free media.
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Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility
Advanced algorithms working from large chemical databases can predict a new chemical’s toxicity better than standard animal tests, suggests a study led by scientists at Johns Hopkins Bloomberg School of Public Health. The study was recently published in Toxicological Sciences.
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ALTEX Publishes Proceedings of the SAP Conferences on Animal Testing 2016-2018
On the occasion of the opening of the Swiss 3R Competence Centre (3RCC) in May 2018, the Swiss  Animal Protection society (SAP) has recently published the proceeding of their Conferences on Animal Testing 2016 - 2018 in ALTEX Proceedings
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Support our activities!
The 3Rs-Centre ULS maintains the 3Rs databases: The Humane Endpoints Websitethe Interspecies Database and the FCS-free Database. These websites contribute to the refinement, reduction and replacement of animals used for research and are free of charge for their users. The website does not receive any financial support and their future relies on donations and gifts. You can help us with keeping these websites available for free by donating a small amount of money for the maintenance and updating of these databases. We are happy with all donations! The 3Rs Program is part of the charitable fund Friends of VetMed, and as such is exempt from any gift or inheritance taxes. This means that 100% of your donation will contribute towards the purpose specified by you.
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Take a look at international workshops, conferences, meetings and online webinars in the online events calendar of the 3Rs-Centre ULS.
Events       »

Contact details
Yalelaan 2
(+31) 30-2538009

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