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Universiteit Utrecht
3Rs-Centre Utrecht Life Sciences
Newsletter, January/February 2019
The mission statement of the 3Rs-Centre Utrecht Life Sciences (ULS) is to stimulate the development, acceptance and implementation of methods which can Replace, Reduce and Refine (the 3Rs) animal experiments. The Centre facilitates the 3Rs in education and animal research in many ways, by providing information and advice about 3Rs models.

The biofabricated liver: A joint effort for personalized medicine and drug development
Dr. Bart Spee and his colleagues are the first scientists to combine the organoid culturing technique with 3D-bioprinting. Their research aims to develop biofabricated liver constructs to predict hepatoxicity and drug treatment efficacy. Besides being pioneers in combining these specific techniques, they also provide a great example of team effort: multiple organizations all play their part in providing expertise in this multidisciplinary research project.
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Winners 3Rs Stimulus Fund UU/UMCU
In 2018 another funding round took place from Utrecht University and the UMC Utrecht’s 3Rs Stimulus Fund. The fund encourages internal innovative research into replacing, reducing and refining animal experiments. In this way, good ideas can become reality, even when the department has limited funding available. There were 16 entries last year, from which six were selected for funding.
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The EURL ECVAM Status Report on the development, validation and regulatory acceptance of alternative methods and approaches is out
The European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) is an integral part of the European Commission's Joint Research Centre (JRC). The EURL ECVAM status report provides updates on the progress made in the development, validation and regulatory acceptance and use of alternative methods and approaches and their dissemination. The status report describes research, development and validation activities, as well as on initiatives that promote the regulatory and international adoption and use of alternative approaches and their dissemination. 
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Nature publication: “Mini-brains” grafted with brain cancer cells may facilitate new and personalized treatments
The Center for Alternatives to Animal Testing (CAAT) at the Johns Hopkins Bloomberg School of Public Health pioneered mass-produced standardized human BrainSpheres (or “mini-brains”) three years ago. Now, in a paper published in Nature’s online journal Scientific Reports, a multidisciplinary team from four institutions has shown how these mini-brains can be used in brain cancer research. 
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Addition of heat source reduces cold stress in laboratory mice
The typical temperature in the ambient environment of mice in laboratories is comfortable for humans, but below the mouse thermoneutral zone. This may result in cold stress in mice, which increases the risk of skewing study results. Recently, a cage has been developed that provides variable cage floor heating, allowing mice to behaviorally regulate body temperature.
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Altex publication: Toward Good In Vitro Reporting Standards
Although many areas of biomedical science have developed reporting standards and checklists to support the adequate reporting of scientific efforts, in vitro research still has no generally accepted criteria. In this paper, the authors pledge for the importance of these reporting standards and provide an overview of initiatives aiming to develop these so-called Good In Vitro Reporting Standards (GIVReSt).
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Support our activities!
The 3Rs-Centre ULS maintains the 3Rs databases: The Humane Endpoints Websitethe Interspecies Database and the FCS-free Database. These websites contribute to the refinement, reduction and replacement of animals used for research and are free of charge for their users. The website does not receive any financial support and their future relies on donations and gifts. You can help us with keeping these websites available for free by donating a small amount of money for the maintenance and updating of these databases. We are happy with all donations! The 3Rs Programme is part of the charitable fund Friends of VetMed, and as such is exempt from any gift or inheritance taxes. This means that 100% of your donation will contribute towards the purpose specified by you.
Show your support       »

Take a look at international workshops, conferences, meetings and online webinars in the online events calendar of the 3Rs-Centre ULS.
Events       »

Contact details
Yalelaan 2
(+31) 30-2538009

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