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Universiteit Utrecht
 
3Rs-Centre Utrecht Life Sciences
Newsletter nr 3-2019
The mission statement of the 3Rs-Centre Utrecht Life Sciences (ULS) is to stimulate the development, acceptance and implementation of methods which can Replace, Reduce and Refine (the 3Rs) animal experiments. The Centre facilitates the 3Rs in education and animal research in many ways, by providing information and advice about 3Rs models.


Quantitative In VitroIn Vivo Extrapolation with in silico tools
To how much of a chemical in our environment do we need to be exposed to fall ill? To answer this question without having to use laboratory animals, many in vitro models have already been developed. But if a substance turns out to be toxic in an in vitro model, how does that exactly translate into toxicity in a living human or animal? Dr. Nynke Kramer is Assistant Professor at the Institute for Risk Assessment Sciences, where she develops computer models that increase the predictive value of in vitro models. These models may support regulatory decision making under the toxicological risk-assessment paradigm shift towards animal replacement.
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Jan van der Valk received Björn Ekwall Memorial Foundation award
Dr. Jan van der Valk, director of the 3Rs-Centre ULS, has been selected as the recipient of the Björn Ekwall Memorial Award for the year 2019. The main goal of the BEMF is to honour the memory of Dr. Björn Ekwall, by giving a reward to the scientists who have substantially contributed to the field of cell toxicology, e.g. by developing new in vitro tests, or via mechanistic or validation studies. The Björn Ekwall Memorial Foundation prize is awarded every year, it is the first time that a Dutch person has received this award.
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Apply now: Advanced In Vitro Models - Summer School Utrecht
Learn about how advanced in vitro models (AIM) hold the potential to reduce animal experimentation by scientific breakthroughs. The convergence of science, technology, legislation and extrapolation modelling in Utrecht are highlighted in this week-long course. This course is comprised of meeting experts, hands-on bench work, modelling and demonstrations. The course allows for a high amount of interaction with lecturers, keynote speakers and fellow participants.
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Stem cell model of motor neuron disease wins International 3Rs Prize 2018
The 2018 International 3Rs Prize, sponsored by GSK, has been awarded to Dr Rickie Patani for work that helps to replace the use of animal models of ALS – an area associated with poor translation and significant animal welfare concerns. Dr Patani, who is based at UCL Queen Square Institute of Neurology and the Francis Crick Institute, worked with a multidisciplinary team to develop and characterise functional motor neurons from patient-derived iPSCs. Their research, published in Cell Reports, provides new insights into the early stages of disease pathogenesis. 

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NVWA annual report ‘Zo Doende 2017’ published
The annual report on animal experimentation in the Netherlands was published in April by the Netherlands Food and Consumer Product Safety Authority (NVWA). The report is only available in Dutch.
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World Congress on Alternatives 2020: Call for Sessions
From 23 to 27 August 2020, the 11th World Congress on Alternatives and Animal Use in the Life Sciences will take place in Maastricht, the Netherlands. The theme is ‘3Rs in Transition’. The multidisciplinary programme covers both traditional 3R themes and new developments of the transition towards animal-free innovations. Your input is very much appreciated. We cordially invite you to send your specific suggestions for symposia, workshops, roundtables or other sessions through the application form that is now available until June 30, 2019.
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Renewed: Brochure for scholars on animal experiments and 3Rs
The 3Rs-Centre ULS has updated the information brochure for scholars on animal experiments and 3Rs. The brochure can be downloaded for free and aims to teach children about the use of animals and 3Rs approaches in research.
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Support our activities!
The 3Rs-Centre ULS maintains the 3Rs databases: The Humane Endpoints Websitethe Interspecies Database and the FCS-free Database. These websites contribute to the refinement, reduction and replacement of animals used for research and are free of charge for their users. The website does not receive any financial support and their future relies on donations and gifts. You can help us with keeping these websites available for free by donating a small amount of money for the maintenance and updating of these databases. We are happy with all donations! The 3Rs Programme is part of the charitable fund Friends of VetMed, and as such is exempt from any gift or inheritance taxes. This means that 100% of your donation will contribute towards the purpose specified by you.
Show your support       »

Take a look at international workshops, conferences, meetings and online webinars in the online events calendar of the 3Rs-Centre ULS.
Events       »



Contact details
Yalelaan 2
3584 CM UTRECHT
(+31) 30-2538009
3RsCentreULS@uu.nl
www.uu.nl/3RsCentreULS

Other 3Rs-Centre ULS websites:
♦ www.humane-endpoints.info
♦ www.interspeciesinfo.com
♦ fcs-free.org


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