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Universiteit Utrecht
3Rs-Centre Utrecht Life Sciences
Newsletter, January 2018
The mission statement of the 3Rs-Centre Utrecht Life Sciences (ULS) is to stimulate the development, acceptance and implementation of methods which can Replace, Reduce and Refine (the 3Rs) animal experiments. The centre facilitates the 3Rs in education and animal research in many ways, by providing information and advice about 3Rs models.

Refining anaesthesia with a supraglottic airway device
Yvonne van Zeeland, a specialist in avian medicine from the Division of Zoological Medicine of Utrecht University’s Clinic for Companion Animals, and her colleagues were awarded a grant from the 3Rs Stimulus Fund for their research proposal “Refining anaesthesia procedures for guinea pigs, rats and mice through the use of species-specific supraglottic airway devices”. This could be a breakthrough in refining animal experiments in which anaesthesia is applied.
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Inventory of 3Rs Knowledge Sources published
A detailed inventory of 800 knowledge sources relevant to the Replacement, Reduction and Refinement of animal procedures used for scientific purposes is now available online. The Joint Research Council (JRC) set out to assess the current situation regarding the sharing of knowledge relevant to the 3Rs with a mind to accelerate the development and uptake of non-animal approaches in research and testing. The findings of the report show that although much 3Rs knowledge exists, its sharing, particularly between sectors and communities can be improved through better coordination, communication and outreach, and by more emphasis on targeted education and training initiatives.
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FDA Launches Predictive Toxicology Roadmap to Enable Advances in Toxicity Testing
The Toxicology Working Group of the FDA laid out FDA’s Predictive Toxicology Roadmap, a six-part framework for integrating predictive toxicology methods into safety and risk assessments.  in many cases, these methods are reducing the need for animal testing – advancing FDA’s long sought goal of refining, reducing, and replacing testing on animals. Among other recommendations, the roadmap calls for FDA research to identify data gaps to ensure that the most promising technologies are developed, validated, and integrated into the product pipeline.
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Tickling rats: a social enrichment to improve rodent welfare
A systematic review, published in PLOS One, examines the current evidence and evaluates the benefits, applications and challenges of tickling as a technique to provide social enrichment for laboratory rats. Designed to mimic the play activity of juvenile rats, tickling has been shown to be an effective means of generating a positive affect (a positive mental state) in these animals.
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EURL ECVAM Status Report 2017 on alternative methods is now available

EURL ECVAM has published its Status Report 2017 presenting an update on the development, validation and regulatory acceptance of alternative methods to animal testing. The report describes all the activities that EURL ECVAM has undertaken since the publication of the previous report (November 2016) to advance the 3Rs in collaboration with many other committed organizations.

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Non-animal testing lab opens in China
A Chinese regulatory institute has opened a non-animal testing laboratory – a model for regulatory bodies to show that implementing alternative methods into government laboratories is achievable, says IIVS president. The Zhejiang Institute for Food and Drug Control (ZJIFDC) is responsible for the regulatory review of food, drugs, and cosmetics produced in Zhejiang province in China. The institute, based near Shanhai, opened the laboratory following collaboration with the Institute for In Vitro Sciences (IIVS), a non-profit organization dedicated to promoting non-animal test methods.
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Call for 2018 Crack-IT challenges
The NC3Rs is now inviting submissions from Sponsors for new Challenges for the 2018 CRACK IT competition. CRACK IT funds collaborations between industry, academics and SMEs to solve scientific challenges which deliver 3Rs and commercial benefits, either by improving business processes or developing a novel technology or approach. As Sponsor of a Challenge you will be able to provide early end user input and access to new technologies that will have 3Rs impact and deliver scientific benefits to your business.
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Workshop report: Animal-Free Inhalation Testing   
In a collaborative effort with government and industry officials, PETA scientists published a workshop report detailing ways to replace animals in inhalation tests. The non-animal approaches include computer modeling and the use of 3-D tissues that can be exposed to test substances in ways that mimic realistic human exposure. This collaborative work is critical to ensure that any new approaches developed will have buy-in from the industries that conduct the research and the regulatory agencies that require that testing be conducted.
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Support our activities! 

The 3Rs-Centre ULS maintains the 3Rs databases: The Humane Endpoints Website, the Interspecies Database and the FCS-free Database. These websites contribute to the refinement, reduction and replacement of animals used for research and are free of charge for their users. The website does not receive any financial support and their future relies on donations and gifts. You can help us with keeping these websites available for free by donating a small amount of money for the maintenance and updating of these databases. We are happy with all donations! The 3Rs Program is part of the charitable fund Friends of VetMed, and as such is exempt from any gift or inheritance taxes. This means that 100% of your donation will contribute towards the purpose specified by you.   
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Take a look at international workshops, conferences, meetings and online webinars in the online events calendar of the 3Rs-Centre ULS.
Events       »

Contact details
Yalelaan 2
(+31) 30-2538009

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